effects of feed restriction and dietary fat type on mrna expression of liver fatty acid-binding protein (l-fabp) in broilers

نویسندگان

bahman navidshad

ghasem hosseini salekdeh

maryam royan

mostafa malecky

چکیده

background: liver fatty acid-binding protein (l-fabp) is the main cytosolic binding site for long chain fatty acids in hepatocytes. fabps enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. objectives: the aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty acid ratio and feed restriction on l-fabp mrna expression. methods: a total of 720, 10-day old male ross 308 broiler chicks were fed diets with unsaturated to saturated fatty acid ratio (u/s) of 2, 3.5, 5, or 6.5 as ad libitum or skip-a-day feeding schedule (during 18–28 days of age). relative expression of l-fabp mrna in hepatocytes of broilers was determined using quantitative reverse transcription real-time polymerase chain reaction. results: our results show that feed restriction induced the expression of l-fabp gene in the liver of broilers. moreover, l-fabp gene expression was increased by dietary u/s ratio of 6.5. there was no interaction between dietary u/s and feed restriction on the l-fabp gene expression. conclusions: results indicate that birds have a mechanism for regulation of fatty acid transfer under different nutritional conditions.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of feed restriction and dietary fat type on mRNA expression of liver fatty acid-binding protein (L-FABP) in broilers

Background: Liver fatty acid-binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids in hepatocytes. FABPs enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. Objectives: The aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...

متن کامل

Liver Type Fatty Acid Binding Protein (L-FABP): A Marker of Contrast Induced -Acute Kidney Injury

Background: Urinary Liver type fatty acid binding protein (L-FABP) is an early biomarker for renal damage. A few studies have been published analyzing the potential use of urinary Liver type fatty acid binding protein (L-FABP) as a biomarker for acute kidney injury. However no study has been done related to Acute Kidney Injury associated with contrast administration. Aim: To search for new mark...

متن کامل

Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker

Abstract Background and objectives: cardiac surgery is often associated with acute kidney injury (AKI). Nowadays, AKI is typically diagnosed by an increase in serum creatinine, which is a delayed and unreliable biomarker. Recent studies recommended using the liver type fatty acid binding protein (L-FABP) as an early biomarker. Material and Methods: The urine samples of 18 adult patients undergo...

متن کامل

Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma

Liver fatty acid-binding protein (L-FABP) is abundant in hepatocytes and known to be involved in lipid metabolism. Overexpression of L-FABP has been reported in various cancers; however, its role in hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated L-FABP and its association with vascular endothelial growth factors (VEGFs) in 90 HCC patients. We found that L-FABP wa...

متن کامل

Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice.

Evidence suggests a relationship between dietary fat intake, obesity, and colorectal cancer, implying a role for fatty acid metabolism in intestinal tumorigenesis that is incompletely understood. Liver fatty acid-binding protein (L-Fabp), a dominant intestinal fatty acid-binding protein, regulates intestinal fatty acid trafficking and metabolism, and L-Fabp deletion attenuates diet-induced obes...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of veterinary medicine

ناشر: دانشگاه تهران

ISSN 2251-8894

دوره 9

شماره 4 2016

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023